Atlético de Madrid and Real Madrid will determine their qualification for the Champions League quarter-finals this Wednesday at the Riyadh Air Metropolitano. The second-leg match of the round of 16 will kick off at 4:00 PM ET (Miami), with Carlo Ancelotti's team holding the advantage after a 2-1 win in the first leg. On the other hand, Diego Simeone's side will need a win to stay in the competition.

The physical condition of Kylian Mbappé is the biggest uncertainty for Real Madrid. The French forward suffered an ankle knock against Rayo Vallecano and will be assessed up until the last minute to determine if he can play. Additionally, the Whites will be without Dani Carvajal, Éder Militao, Jesús Vallejo, and Dani Ceballos. For Atlético, the main doubt is Clement Lenglet, who is carrying some discomfort, but he has been included in the squad. On the other hand, Koke Resurrección is ready to return after overcoming his muscle injury.

Atlético's coach, Diego Simeone, praised his rival ahead of the match: "Ancelotti is much better than me," said the Argentine, acknowledging the Italian's experience on the bench. Meanwhile, Carlo Ancelotti, the Real Madrid coach, stressed that his team must be prepared for a highly intense game in a stadium where they have never won in the Champions League.

Facts and background

• Atlético de Madrid has never eliminated Real Madrid in a Champions League knockout tie.
• In the three previous times the Madrid team won 2-1 in the first leg at home, they advanced twice and were eliminated once (against Juventus).
• Julián Álvarez, Atlético's forward, comes into this match in form with five goals in his last five games.
• However, Antoine Griezmann has scored in only one of his last eight matches.
• Real Madrid averages 2.5 goals per game in this Champions League season, with 28 goals in 11 matches.

With Arsenal waiting in the next round, the Madrid derby will be a highly charged encounter at the Metropolitano. Real Madrid will look to hold on to their advantage and make the most of their offensive efficiency, while Atlético de Madrid will rely on their intensity and the support of their fans to try for a comeback.