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The Reds welcome EFL League Two side Accrington to Anfield for the first meeting between the two sides in all competitions. 

John Doolan's side currently sits 19th on the fourth tier table, with only Harrogate Town, Morecambe, Tamworth and Dagenham and Redbridge below them in the English football pyramid left in the competition. 

Liverpool was last knocked out of the FA Cup at the third round stage in 2018-2019 against Wolverhampton Wanderers, and Slot has warned his players not to get caught up in the occasion to avoid an early exit.

"I think every team that plays against us is a special occasion for every team we face, but especially for a lower-league team, so they will be all up for it," Slot said.

"They've lived towards this game for weeks, probably.

"If you go to a Champions League final, everybody is hyped up and ready and that is for them ... it is going to feel as if it is a Champions League final, so we have to be aware of that.

"Nine out of 10 times in the first 25 minutes, half hour is the most difficult part of the game, because they will still be very intense.

"It is up to us to be ready for them wanting to play the best game of their lives and that is what we have to do as well."

Slot was also able to provide some early team news ahead of the game, with the Liverpool boss expected to heavily rotate his squad after its Carabao Cup semi-final first leg defeat to Tottenham Hotspur.

Despite being forced off in the first half at Tottenham Hotspur Stadium, Jarell Quansah is expected to return while Dominik Szoboszlai has recovered from his illness.

Trey Nyoni and Rio Ngumoha, who have impressed for the Reds' academy, could also feature, and there could be some rare minutes for summer arrival Federico Chiesa.

Since joining from Juventus in August, Chiesa has made just four appearances in all competitions after picking up a muscle injury at the start of his career on Merseyside.

The Italy international has since returned from that setback but has yet to feature for the Reds, with Slot saying he must continue to compete with the club's star forward players.

"Every game is a chance for everyone to get some playing time, it's not only for him been difficult because all the things you said, in terms of match fitness, also that he has to compete with Cody Gakpo, Luis Diaz, Diogo Jota, Darwin Nunez, Mo Salah," Slot said.

"Everyone knows the numbers Salah brings, there are not many reasons to bring him out, and he is also so fit. He was the fittest player that came in pre-season. And he does everything to keep his match fitness.

"So it is not only about Federico with his limited playing time. He definitely has to deal with the way he came in. The rest were already training a lot, and we had to bring him in to get match fitness.

"It's a combination of reasons. Let's see how much he can help us, because the second half is more important than the first."