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The Brazil international was forced off six minutes into Juve's 3-2 win over Leipzig, with the club confirming the extent of his injury.

Bremer has been key to Thiago Motta's side so far this season, playing every minute in Serie A with the team yet to concede a single goal in six matches.

Among his team-mates, he has played the most minutes (540), making the most interceptions (six) and blocks (11).

Juventus was also dealt another blow, with midfielder Nico Gonzalez suffering a thigh muscle injury.

"Bremer and Nico Gonzalez underwent diagnostic tests which revealed an anterior cruciate ligament injury in the left knee for the former and a low-grade injury to the rectus femoris of the right thigh for the latter," the club said in a statement.

"Bremer will undergo surgery in the coming days."