Chelsea haven't won a domestic trophy since lifting the FA Cup in 2018 and their wait will go on for another season after they blew the lead at the Amex Stadium.

Enzo Maresca's side were gifted the lead in the fifth minute when Brighton keeper Bart Verbruggen fumbled Cole Palmer's cross into his own net.

It was a horrendous mistake but Chelsea failed to press home their advantage.

Thrashed 7-0 at Nottingham Forest in the Premier League last weekend, Brighton bounced back impressively from the second worst defeat in the club's 123-year history.

They equalised in the 12th minute as Joel Veltman's cross reached Georginio Rutter, who found space between Chelsea defenders Trevoh Chalobah and Tosin Adarabioyo to flick a header into the far corner.

And Brighton completed their fightback in the 57th minute when Mitoma clipped a deft finish past Chelsea keeper Robert Sanchez despite the visitors' claim for handball.

At Brisbane Road, Manchester City were rocked when Jamie Donley's long-range effort came back off the bar and rebounded in off City goalkeeper Stefan Ortega to give Orient an early lead.

The English champions finally drew level after 56 minutes when Uzbekistan defender Abdukodir Khusanov deflected in Rico Lewis's shot for his first goal since signing for City from Lens in the January transfer window.

City boss Pep Guardiola had to turn to his bench more than he would have liked just four days before a mammoth Champions League play-off round first leg against Real Madrid.

But the introduction of De Bruyne made the difference as the Belgian midfielder scored 11 minutes from time.

"It was a typical FA Cup game, that is why this competition is unbelievable. For the fans, how the crowd support and we knew they are strong," Guardiola said.

Victory came at a cost for City, though, as new midfielder Nico Gonzalez hobbled off just 22 minutes into his debut after a £50 million ($62 million) move from Porto.

Southampton stunned 

Newcastle came from behind to win 3-2 against Birmingham at St Andrew's.

Birmingham led after 42 seconds through Ethan Laird's deflected strike.

A quickfire double from Joe Willock and Callum Wilson turned the tie in Newcastle's favour, but Tomoki Iwata's blistering strike levelled before half-time for the League One leaders.

Newcastle, though, rounded off a fine week after reaching the League Cup final on Wednesday as Willock restored their lead on 82 minutes.

Bottom of the Premier League and seemingly destined for relegation, Southampton got no respite in the FA Cup as Burnley won 1-0 at St Mary's.

Scott Parker's team went in front after 77 minutes when Marcus Edwards scored from close range on his debut after signing on loan from Sporting Lisbon.

It is almost 600 minutes since Championship promotion chasers Burnley last conceded a goal, with 10 clean sheets in their last 11 games.

In the last FA Cup tie at Goodison Park, Everton, who are moving to a new stadium next season, were beaten 2-0 by Bournemouth thanks to goals from Antoine Semenyo and Dan Jebbison.

Rodrigo Muniz scored twice as Fulham won 2-1 at League One Wigan.

Ipswich, second bottom of the Premier League, swept to a 4-1 win against Frank Lampard's Coventry.

George Hirst's second-minute penalty was quickly cancelled by out Joel Latibeaudiere's eighth-minute equaliser for the second-tier hosts.

But Jack Clarke restored Ipswich's lead in the 28th minute and struck again after 37 minutes before Jaden Philogene's 63rd-minute effort sealed the rout.

Millwall reached the fifth round for the first time since 2018-19 thanks to Femi Azeez's double in a 2-0 win at Championship leaders Leeds.