Former Premier League duo Dusan Tadic and Edin Dzeko scored in the first half for Fenerbahce before Morocco international Youssef En-Nesyri headed in a third for the Turkish side to give them full control.

Mourinho won the competition with Porto in 2003 and again with Manchester United in 2017, also reaching the final when he was in charge of Roma two years ago.

Real Sociedad will return to Spain in a commanding position after a penalty from Brais Mendez and terrific goal by Japan winger Takefusa Kubo saw them past Danish Midtjylland, who pulled one back through Adam Buksa.

The winners of the tie will play United or Tottenham in the last 16.

Ajax took charge of their play-off against Belgian outfit Union Saint-Gilloise with a 2-0 victory in Brussels.

Christian Rasmussen steered the Dutch club ahead just before the hour, with 16-year-old Jorthy Mokio volleying in a second from 20 yards.

 and Ferecvaros won 1-0 against Viktoria Plzen.