Klara Buehl gave Bayern hope with a first-half strike that reduced Lyon's two-goal advantage from last week's first leg in Germany.

Lyon levelled on the night moments into the second half through Melchie Dumornay's header before Kadidiatou Diani punished a defensive error to put the French champions in complete control.

Malawi international Tabitha Chawinga grabbed Lyon's third and former Ballon d'Or winner Ada Hegerberg came off the bench to round off the scoring in stoppage time.

Three-time winners Barcelona hold a 4-1 lead over Wolfsburg ahead of Thursday's quarter-final, second leg in Spain.

Meanwhile, English champions Chelsea must follow Arsenal's lead in overturning a two-goal first leg deficit against Manchester City.