Colombia will rue its profligacy in front of goal but should take encouragement from dominating quality European opposition for large periods as it heads to Kansas City as group winner to take on Ghana next weekend.

Portugal, which needed to win to top the group, travels north to Toronto to play Croatia on Friday (AEST) knowing it has not quite yet found a way to blend all the talent in its squad into an effective team.

The match started to a cacophony of noise from the massed ranks of yellow-shirted Colombia supporters and the decibel levels went up a notch when striker Jhon Cordoba headed the ball over the bar in the first minute.

Jhon Arias caused Portugal problems every time he ran at its defence and he set Cordoba free in the 17th minute, the big target man unleashing a rocket of a shot that keeper Diogo Costa did well to stop.

After a lovely flowing move five minutes later, winger Arias took the shot himself and screwed the ball towards the far corner of the net only for Ruben Neves to arrive just in time to flick it off the line.

Colombia struggled to clear its lines cleanly sometimes, however, and it was this frailty that allowed Portugal its best chances towards the end of the first half.

Bruno Fernandes found himself free in front of goal in the 39th minute, his shot bringing a fine point-blank save out of Camilo Vargas in the Colombia goal.

Three minutes before halftime, Joao Felix cleverly chested the ball over a defender and flashed an acrobatic volley over the bar.

Colombia pressed forward looking for the goal its dominance deserved and both Gustavo Puerta and playmaker James Rodriguez troubled the goalkeeper with shots before the break.

Portugal attacked more after the break but it was Colombia that continued to carve out the best chances with Arias setting up substitute Richard Rios for a shot that went wide.

Arias curled a shot at goal that was well saved by Costa and Puerta drilled another chance wide just before the hydration break.

A Rodriguez volley was deflected away from its target in the 73rd minute just before he and Arias were substituted but Colombia continued to tear forward at every opportunity.

Davinson Sanchez thought he had scored the winner with a far post header a minute from time but it was called back for a very tight offside after a video assistant referee (VAR) check.

Rafael Leao went close to winning it for Portugal in stoppage-time with a shot that flashed across goal before the referee finally called time on the entertaining match played out in front of a crowd of 64,478 sweltering in the Miami evening heat.

Portugal's totem Cristiano Ronaldo, booed every time he touched the ball and starved of service, had barely a sniff of a chance, his one shot on target a long-range free-kick that went straight to the goalkeeper.