Pochettino's side ran riot in the first half with four goals in 25 minutes, with Uruguay seeing captain Rodrigo Bentancur sent off just after the hour for a second bookable offence. 

Sebastian Berhalter opened the scoring in the 17th minute after playing a short one-two with Sergino Dest from a free-kick before sensationally picking out the top-right corner. 

US doubled its lead three minutes later with Berhalter involved again, with his in-swinging corner towards the back post met by the head of Alexander Freeman. 

Freeman bagged his brace after his brilliant driving run from the right-hand side ended with a fierce finish beyond Cristopher Fiermarin at his near post in the 31st minute. 

Three minutes before half-time, Diego Luna grabbed the host's fourth of the match when he tucked Timothy Tillman's scuffed pull-back into the bottom-left corner of the net. 

Though Giorgian de Arrascaeta's exquisite bicycle kick reduced the arrears in first-half stoppage time, Uruguay's hopes of getting back into the game were quickly extinguished in the 64th minute when Bentancur was given his marching orders for a high challenge on Berhalter. 

Tanner Tessmann made that man advantage count four minutes later, flicking Giovanni Reyna's cross home to complete an emphatic display by the World Cup co-host.