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Napoli will hope to make it third time lucky after it lost back-to-back games against Lazio in December which saw it exit the Coppa Italia at the first hurdle and lose top spot in the standings to Atalanta.

Antonio Conte's men have since regained their place at the summit, putting together a run of eight successive wins before their progress was slowed with consecutive draws against Roma and Udinese.

Inter failed to take advantage of Napoli's dip, drawing the derby with AC Milan before slumping to a 3-0 defeat in its rescheduled game with Fiorentina last week.

Inter bounced back from that defeat to Fiorentina to beat the same opposition 2-1 at the San Siro on Tuesday, and with the same amount of games now played, Napoli is clinging to first place by the slimmest of margins.

Conte has been dealt a serious blow with David Neres suffering a thigh injury against Udinese, and the Brazilian winger could be out of action for at least a month.

Neres has started Napoli's last nine games, ever since Khvicha Kvaratskhelia's injury in the 1-0 loss to Lazio in December, and was seen as an able replacement now that the Georgian has left for Paris Saint-Germain.

Giacomo Raspadori will likely replace Neres against Lazio, which come into this tie on the back of two league wins. Lazio lies fourth in the standings, 10 points off Napoli.

Lazio can be buoyed by recent history.

Napoli has not won any of their last four games against Lazio in Serie A (D1 L3), after having won each of the previous four.

Inter and Juventus, meanwhile, were involved in one of the season's most entertaining games when they drew 4-4 at the San Siro in October.

That was one of 13 league draws this season for Juventus, which leaves it out of the Scudetto battle in fifth place and 12 points behind Napoli, but it confidence has been boosted by recent form.

Juve suffered its first league defeat of the season at Napoli last month, but has since won two on the bounce and Randal Kolo Muani has netted five times in three league games since arriving on loan from PSG.

Inter has injury doubts, with both Marcus Thuram and Marko Arnautovic going off with knocks in the win over Fiorentina.

The Nerazzurri are unbeaten in their last three league matches against Juventus (W1 D2); in the last 45 years (since 1980) only once have they recorded four consecutive matches without defeat against the Bianconeri in Serie A

Atalanta, third in the standings and five points off top spot, will look to take advantage of any slip-ups by Napoli and Inter when it hosts Cagliari on Sunday.

Seventh-placed AC Milan has a home game against Hellas Verona.