Luis de la Fuente backed his Spain side to step-up in their Nations League clash against Serbia, despite being without a plethora of their "irreplaceable" players.

Spain know a victory over Tuesday's opponents will put them within touching distance of qualification, having taken seven points from their first three games. 

However, De la Fuente will be without Barcelona's Lamine Yamal for the clash in Cordoba, with the 17-year-old the latest name to withdraw from La Roja's ranks. 

Yamal limped off in the 93rd minute of their Nations League win over Denmark before returning to Barcelona to undergo further tests, revealing he suffered a hamstring strain.

"(Yamal) is irreplaceable," De la Fuente told a press conference on Monday. "(But) we have to play eleven and whoever replaces him will want to make a statement.

"Lamine is fantastic, but... you have to understand that, in this life, nobody gives anything away for free. Whoever has to replace him, I'm sure they will do it very well."

Yamal has since been replaced in the squad by Atletico Madrid's Rodrigo Riquelme, who will be hoping to make an impact against Serbia. 

Yamal's absence only added to Spain's injury woes, with the European champions now without seven key players for the visit of Dragan Stojkovic's side.

Nico Williams, Unai Simon, Dani Carvajal, Robin Le Normand, Rodri and Dani Olmo, who all starred in their Euro 2024 success, are all also unavailable due to injury. 

"They are (too) irreplaceable, each one brings different things to the table. But we are lucky that this is a national team and the best players come here," De la Fuente said.

"I never miss anyone, because those who are playing are (also) very good.

"Obviously, we don't work with closed blocks as it happens at club level, but we also have players who have been here for a long time and internalise the messages.

"In a club you have much more time to do many more things than we do."